Deve ser feito no evento DrawColumnCel.
Segue exemplo abaixo
procedure TfrmGridInsereAltera.UniDBGrid1DrawColumnCell(Sender: TObject; ACol, ARow: Integer; Column: TUniDBGridColumn; Attribs: TUniCellAttribs); begin Column.Title.Font.Size := 10; Column.Title.Font.Color := clBlue; Column.Title.Font.Style:=[fsBold]; if ACol=0 then begin Attribs.Color:=clLtGray; Attribs.Font.Style:=[fsBold];
Column.Title.Font.Size := 9; Column.Title.Font.Color := clRed; Column.Title.Font.Style:=[fsBold];
end; end;
Espero que resolva.